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- During Therapy
- After Therapy
- Add-Back Therapy
- Product Information
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After Therapy

After completing 6 months of Lupron Depot® therapy, your hormone levels will start returning to normal. This can have an effect on your menstrual cycle, as well as on any side effects you may have experienced during therapy.

Symptom relief

Many women experienced 12 months of relief from symptoms, such as pelvic pain and pelvic tenderness, after 6 months of therapy. Of course, individual results may vary.

Your menstrual cycle

For most women, menstrual periods return 2 months after stopping treatment with Lupron Depot. If your period has not returned after 3 months, talk with your doctor.

Your side effects

If you have been having side effects typical of low estrogen levels, they generally subside gradually once treatment is completed.

If your pain returns

If your symptoms return after you stop using Lupron Depot, your doctor can prescribe an additional 6 months of treatment along with add-back therapy. Add-back therapy is a pill (norethindrone acetate 5 mg daily) that adds back low levels of a hormone without interfering with the effectiveness of Lupron Depot. It significantly reduces the bone density loss associated with the use of Lupron Depot. It can also help reduce hot flashes.

Please see below for important information on Lupron Depot®, including side effects.

*Norethindrone acetate 5mg daily

 
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Important Safety and Other Information:

Lupron Depot® is indicated for management of endometriosis, including pain relief and reduction of endometriotic lesions. Lupron Depot with norethindrone acetate 5 mg daily is also indicated for initial management of endometriosis and for management of recurrence of symptoms. Duration of initial treatment or retreatment should be limited to 6 months.

Most common side effects with Lupron Depot are generally those related to low estrogen levels, including hot flashes, headaches, and vaginal dryness. A small amount of bone loss (average 3.2% at month 6) may also occur during therapy with Lupron Depot alone.

The most commonly reported side effects of Lupron Depot plus norethindrone acetate 5 mg daily are hot flashes, headache, nausea/vomiting, depression/emotional liability, and asthenia. In addition, Lupron Depot plus norethindrone acetate-treated patients had significantly decreased HDL levels and significantly increased LDL/HDL rations. After treatment, mean serum lipid levels in patients with follow-up data returned to pretreatment values. Norethindrone acetate should be used with caution in women with cardiovascular risk factors including lipid abnormalities and cigarette smoking. Please refer to the norethindrone acetate prescribing information for warnings, precautions, contraindications, and adverse reactions.

Please see Complete Prescribing Information, as well as the Patient Product Information for Lupron Depot.
 
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