Do Not Take LUPRON DEPOT if:
  • You should not receive LUPRON DEPOT if you are or may become pregnant, are breast-feeding, have undiagnosed vaginal bleeding, or if you have experienced any type of allergic reaction to LUPRON DEPOT or similar drugs.
  • You should not receive Add-back* plus LUPRON DEPOT if you currently have or have had any clotting disorder, heart disease, stroke, impaired liver function or liver disease, or breast cancer.

*Norethindrone acetate 5 mg.
Reference: LUPRON DEPOT [package insert].

Before Starting Treatment
  • You should know that LUPRON DEPOT is not a method of birth control and unprotected intercourse could result in pregnancy. To prevent pregnancy, you should use a non-hormonal form of birth control such as condoms, a diaphragm with contraceptive jelly, or a copper IUD.
  • You should know that if you miss doses of LUPRON DEPOT, you may experience breakthrough bleeding and ovulation can occur.
  • You should know there is a possibility of the development or worsening of depression and/or the occurrence of forgetfulness.
  • You should know that convulsions have been observed in patients taking leuprolide acetate.

Reference: LUPRON DEPOT [package insert].

LUPRON DEPOT and Bone Loss
  • Thinning of the bones may occur during therapy with LUPRON DEPOT alone, which may not be completely reversible in some patients.
  • If you smoke, use alcohol in excess, have a family history of osteoporosis, or are taking other medications that can cause thinning of the bones, treatment with LUPRON DEPOT alone is not recommended and combination with Add-back* should be considered.
  • Add-back* therapy can help reduce the bone loss that occurs with the use of LUPRON DEPOT alone.
  • If you and your doctor are considering a second course of treatment, bone mineral testing is recommended and retreatment with LUPRON DEPOT should include Add-back* therapy.

*Norethindrone acetate 5 mg.
Reference: LUPRON DEPOT [package insert].

Tell Your Doctor
  • Tell your doctor right away if you think you are pregnant before or during LUPRON DEPOT treatment.
  • Before taking Add-back*, tell your doctor if you currently have or have had high cholesterol, migraines, epilepsy, or depression, or if you smoke.
  • During treatment with Add-back*, tell your doctor right away if you have a sudden loss of vision or double vision, or if migraine headaches occur.
  • Because Add-back* may cause some degree of fluid retention, tell your doctor if you experience fluid retention, seizure, asthma or worsening of asthmatic symptoms, or heart or kidney problems.

*Norethindrone acetate 5 mg.
Reference: LUPRON DEPOT [package insert].

What to Expect
  • Your estrogen levels will increase for 1 or 2 weeks after beginning LUPRON DEPOT. During this time, you may notice an increase in your current symptoms. You should notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
  • It is common for your periods to stop with effective doses of LUPRON DEPOT. Tell your doctor if you continue to have regular periods while receiving treatment.

Reference: LUPRON DEPOT [package insert].

Side Effects
  • The most common side effects of LUPRON DEPOT include hot flashes, vaginal dryness, headaches, changes in mood, decreased interest in sex, depression, and/or the occurrence of forgetfulness.

Reference: LUPRON DEPOT [package insert].

Helpful Resources

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org or call the toll-free phone number (1-888-4PPA-NOW) for assistance.